ABSTRACT
Background CORONAVIRUS disease 2019 (COVID-19) is a viral infectious disease caused by the single-stranded, enveloped RNA virus, severe acute respiratory syndrome coronavirus-2 (SARS COV-2). Though Covid-19 is an acute viral infection predominantly affecting the respiratory system, it has short-term, long-term metabolism and endocrine complications. Being a global pandemic with a high rate of recovery, it is expected to have many long-term metabolic complications in a vast number of covid-19 survivors. We aimed to find out the post covid complications in patients discha Objective: rged from SARI ward AIIMS Bathinda, Punjab. Design: Settings: Prospective observational study OPD and telemedicine consultation of the patients admitted to the tertiary hospital Material and Methods: - A prospective study was done on 244 patients with COVID -19 RAT, and RTPCR Positive patients were done. Patients were followed up in OPD and by telemedicine for post covid complications. Main outcome measures: The main outcome measures were measured in terms of mortality as well as morbidity. Morbidity was evaluated in terms of the complications developing after covid or persistence of the complications developed during the covid. All the patients who were admitted Sample size: to our tertiary Centre were followed for post covid complications. Result: - Out of 244 patients that were analyzed, 22% died during the disease, and 78% survived. Out of the patient who survived 64.8% developed post covid complications. 35.8% complained of fatigue, 10.5% developed headache, 8.9% developed body aches, 3.2% had a persistent cough, 1.6% had a sore throat and 1.1% had gastrointestinal symptoms. Conclusion: - In this population-based study large no. of patients suffer from long-term residual effects afterward-CoV-2 infection such as fatigue, cough, headache, dyspnea, and decline in quality of the eye. With a large range majority of people infected all over the world, our findings emphasize the need for timely planning of resources and patient care. Multidisciplinary collaboration is essential to provide integrated outpatient care for the survival of acute COVID-19. Limitation: Small sample size
ABSTRACT
Background: Cirrhosis of liver is considered as chronicdisease of liver characterised by the triad of parenchymalinflammation, necrosis and regeneration with diffuse increasein fibrosis and formation of nodules around regenerating liverparenchyma. A retrospective study of 90 patients of livercirrhosis visiting OPD/Indoor of SGRDIMSR, Vallah, SriAmritsar were included in the study conducted from Jan 2017to Aug 2018 to assess QTc interval in patients with cirrhosis ofliver due to any etiology and to find the correlation betweenQTc interval and severity of liver cirrhosis as per Child-PughScore.Methods: The severity of liver cirrhosis was assessed andaccording to the Child Pugh Score, divided into Class A, ClassB and Class C of 30 patients each. QT interval was noted in allthe patients. QTc was calculated by Bazett’s formula. Fromabove parameters we try to find out whether there is anycorrelation between QTc and severity of disease.Results: The mean value of calculated QTc interval in: ClassA=0.474; Class B=0.490 and Class C=0.583. The QTc intervalincreased linearly with the severity of the disease and the pvalue was less than 0.001 which is highly significant.Conclusion: In our study we concluded that the prolongationof QTc interval is co-related with liver function and itsprevalence increases with the severity of liver dysfunction.Prolongation of the QTc interval was statistically confirmed inChild-Pugh C and B. The prolonged Q-T interval predictssevere arrhythmias and sudden death, and they are the idealcandidates for liver transplantation.
ABSTRACT
Background: Diabetes Mellitus is a condition known for itschronic complications such as retinopathy, neuropathy andnephropathy. The objective of this study was to evaluate serumhomocysteine levels in patients of diabetes mellitus and tocorrelate serum homocysteine levels with albuminuria indiabetics.Methods: The study was single centric study undertaken in theDepartment of Medicine at SGRD Institute of Medical Sciencesand Research, Amritsar. It was a case control study with 100patients diagnosed as type 2 diabetes mellitus as per theAmerican Diabetic Association guidelines and attendingDepartment of Medicine, SGRDIMSR, Vallah, Sri Amritsar. Thepatients were divided into two groups. Study group consisted of50 patients with type 2 diabetes having albuminuria & controlgroup comprised of 50 patients of type 2 diabetes mellituswithout albuminuria. Serum homocysteine levels weremeasured in the patients of both the groups.Results: It was observed that Serum homocysteine levelswere significantly raised in diabetic patients with albuminuria (pvalue = <0.001). In the study, serum homocysteine levels wereincreased in patients with macroalbuminuria in comparison tomicroalbuminuria (p value = 0.001).Conclusions: Our study demonstrated that a significantelevation in serum homocysteine levels was seen in patientswith diabetic nephropathy. The increase in homocysteine levelsis proportional to decline in creatinine clearance and to thedegree of albuminuria.
ABSTRACT
Cancer is a major public health burden in both developed and developing countries. Plant-derived compounds have been an important source of several clinically useful anti-cancer agents including taxol, vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, and etoposide derived from epipodophyllotoxin are in clinical use all over the world. About 30 plant derived compounds have been isolated so far and are currently under clinical trials. Cancer chemopreventive agents, many of which are natural products, are capable of preventing or inhibiting the process of carcinogenesis. As with other pharmaceutical agents useful for disease prevention, a pharmacoeconomic analysis of a cancer chemopreventive formulation would need to be considered, and the composition of the formulation should improve over time. A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol, roscovitine, combretastatin A-4 phosphate , betulinic acid and silvestrol are in clinical or preclinical development.